HDFx- A Potential Fighter against Cytokine Storms



Scientific Federation took initiative in the field of Flu science by introducing journal in the year of 2017. Our main intention is to support and promote a high quality comprehensive evidence-based on the recent research from the highly qualified authors. We received an article from Prof. Burton M. Altura based on his recent research work on HDFx: A Novel Immunomodulator and Potential Fighter Against Cytokine Storms in Viral Flu Infections.

       The first significant step towards preventing from flu was made by Jonas Salk and Thomas Francis after it was discovered that viruses that is mainly types of influenza virus A, B, and C rarely cause flu. This built on work by Australian Frank Macfarlane Burnet, who showed that the virus lost virulence when it was cultured in fertilized hen's eggs. This Application was observed by Francis who allowed his group of researchers to develop the first influenza vaccine, with support from the U.S. Army. It was first utilized to protect the U.S. military forces against the flu when the Army was deeply involved in this research due to its experience of influenza in World War. 

       Numerous pathophysiological responses, in the body, take place after infection by flu viruses. The classical clinical signs are high fevers, coughs, headaches, muscle and joint pain, and severe fatigue. The lungs become severely inflamed, by overproduction of a host of mediators, i.e., cytokines or chemokines, can cause severe tissue damage and hemorrhages, followed by death. It must be noted, that surgically-operated hospitalized patients are often at great risk for developing influenza infections which result in severe “cytokine storms”. 

       A new host-defense factor was discovered and termed as “HDFx”, that is a conserved protein found, so far, in rats, mice, guinea-pigs, rabbits, dogs, and subhuman primates. “HDFx” as being a protein molecule that possesses such vasoactive properties that manipulates the microcirculation and curtails bleeding, even in the lungs. After many great experiments in the laboratories it is clearly shown that it is protective to varying degrees against a variety of systemic bodily insults, ranging from hemorrhage, trauma, combined injuries, endotoxins, a variety of lethal bacteria. A unique attribute of “HDFx” is its ability to protect against cytokine storms and it will induce a “supercharged effect” in macrophages, NK cells, lymphocytes, Kupffer cells. 

       “HDFx” is a biologic host-defense protein may provide a unique way to ameliorate and prevent the “cytokine storms” and hemorrhages in severe influenza infections.

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